Great, but not yet Professional..
I enjoyed the writing of this cartoon a lot, and see a lot of potential for it to get picked up (with some talented animators and voice actors on board), but there are a few things I think would need to change. First of all, the references to pokemon and video games, while entirely acceptable in the NG community, would feel very out of place and somewhat childish (sorry, but true) as part of a real network show. Second, while the characters were all around funny (like the alcoholic lions), they all would need a bit more flushing out. I can't help comparing this heavily to Venture Bros. (like you mentioned in your post), and I think just as each VB character, regardless of significance or screen time (the monarch minions pair, etc) has a distinct humor-driven personality, I think each of your minor characters (the lions, even the sidekick monkey, especially his darker friend helping with the suitcase) needs to be more defined. If you, for yourself, were to write extensive character descriptions for each, and then had those more complex characters reflected in the dialogue, it would make the cartoon overall much funnier.
Best of luck getting a crew and getting the show picked up! I think you'll do great.